Which of the
following is true about the role of theophylline in the treatment of
acute asthma?
A) Theophylline/aminophylline should be used in cases unresponsive to 2–3 doses of nebulized albuterol since it has added benefits when used with an inhaled beta-agonist.
A) Theophylline/aminophylline should be used in cases unresponsive to 2–3 doses of nebulized albuterol since it has added benefits when used with an inhaled beta-agonist.
B) Patients
who get theophylline/aminophylline have more side effects than do patients who
get continuously nebulized albuterol and get no benefit from the drug.
C) If you choose to use theophylline/aminophylline the therapeutic goal is a serum level of 20 micrograms/dL.
D) None of the above is correct.
C) If you choose to use theophylline/aminophylline the therapeutic goal is a serum level of 20 micrograms/dL.
D) None of the above is correct.
Discussion
The correct answer is B. Patients who are treated with theophylline have more side effects, including tachycardia, nausea, and arrhythmias, than do patients who get continuously nebulized albuterol. Theophylline/
aminophylline have essentially no role in the treatment of acute asthma exacerbations. There is no benefit to theophylline or aminophylline over optimal beta agonist therapy (eg, continuous nebulized albuterol if
required). Answer C is incorrect because if used at all, the therapeutic goal for theophylline is a serum level of 15 micrograms/dL.
The correct answer is B. Patients who are treated with theophylline have more side effects, including tachycardia, nausea, and arrhythmias, than do patients who get continuously nebulized albuterol. Theophylline/
aminophylline have essentially no role in the treatment of acute asthma exacerbations. There is no benefit to theophylline or aminophylline over optimal beta agonist therapy (eg, continuous nebulized albuterol if
required). Answer C is incorrect because if used at all, the therapeutic goal for theophylline is a serum level of 15 micrograms/dL.
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